Heterogeneous ontogeny of erythropoiesis after bone marrow ablation and allogeneic bone marrow grafting.
نویسندگان
چکیده
Thirty-two patients who underwent bone marrow transplantation for hematologic malignancies were studied for hemoglobin-F as an indicator for fetal erythropoiesis. Two different patterns of response were noted. One group of patients who had an elevated HbF level prior to marrow grafting later showed a marked reactivation of HbF synthesis, whereas the other group of patients who had normal HbF levels prior to transplantation failed to exhibit such an increase. This phenomenon occurred independently of ages of marrow graft donors or recipients, the type of underlying hematologic malignancy, or remission induction therapy prior to preparation for transplantation, pretransplant hemoglobin levels, transfusion with red blood cells, red cell volume, and production of reticulocytes.
منابع مشابه
Ontogeny of Erythropoiesis After Bone Marrow Ablation and Allogeneic Bone Marrow Grafting
H UMAN and several other mammalian species sequentially express different globin genes during ontogeny, or during periods of “stress,” such as hypoxemia or anemia. Hemoglobin ontogeny in humans includes three distinct phases. The “embryonic” phase predominates from the 5th to the 16th week of gestation. In this period, embryonic hemoglobin chains are and . Throughout the remainder of gestation ...
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ورودعنوان ژورنال:
- Blood
دوره 61 1 شماره
صفحات -
تاریخ انتشار 1983